External factors
| Category: |
Chemical compounds |
| Experimental category: |
HL |
| Experiment: |
Cell morphological analysis//SA-β-gal activity assay//Telomerase activity assay |
| Description: |
Under the microscope field,we found that the total number of healthy HL60 cells significantly decreased after TSY -1 treatment.After treatment,the dark blue staining became larger and denser,and the percentage of labeling cells also increased in HL60 cells.With the treatment of TSY -1, the Telomerase activity decreased significantly in HL60 cells. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
Western blot combined with immunoprecipitation showed that TERT protein level in HL60 cells decreased significantly after TSY-1 treatment by a dose-dependent manner . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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