External factors
| External factors: |
γ-irradiation |
| Experiment: |
SA-β-gal activity assay |
| Description: |
The senescence-associated β-galactosidase (SA-β-gal)staining showed that p73 knockdown significantly increased the proportion of positive cells (~89.1% in p73i-1 and 79.7% in p73i-2 transfected cells) at 5 dpi, compared to the irradiated controls (~41.2%). |
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Regulatory relationship
| R-EF-Target gene:
|
Activation |
| Target gene experiment: |
Flow cytometry |
| Target gene description: |
The proportion of cells in the G2 phase increased significantly in irradiated p73-knockdown cells(30.2% in p73i-1 and 27.2% in p73i-2 transfected cells),compared to that in irradiated control cells (17.8%). |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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