External factors
| External factors: |
HCV infection |
| Experiment: |
Flow cytometry//qRT-PCR//Western blot// FISH |
| Description: |
Remarkably, at day 3 of TCR stimulation,CD57 expression on CD4+CD45RA+na?ve T cells was significantly increased in HCV patients compared with HS .HCV na?ve T cells exhibited higher mRNA levels of CDKN1A (encodes p21cip1), CDKN2A (encodes p16ink4a), and p53, as determined by real-time RT-PCR. However, we observed increases in p53 protein expression and cleaved poly ADP-ribose polymerase 1 (PARP-1) in unstimulated memory CD4 T cells,as well as increases in p21 and γH2AX levels in TCR-stimulated memory CD4 T cells derived from HCV patients. Telomere length was significantly shortened in HCV-derived total CD4 T cells,as well as in na?ve and memory CD4 T cells compared with HS. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
TERF2 |
| Target gene experiment: |
Western blot |
| Target gene description: |
The TRF2 protein level was significantly downregulated in na?ve CD4 T cells isolated from HCV patients. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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