External factors
| External factors: |
4-hydroxynonenal |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis |
| Description: |
Treatment with 10 lM 4-HNE increased the proportion of senescent cells, demonstrated by cellular enlargement and positive staining for SA-β-gal . |
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Regulatory relationship
| Target gene:
|
TXNIP//PPARD |
| R-EF-Target gene:
|
Upregulation//Activation |
| Official symbol(s): |
TXNIP//PPARD |
| Target gene experiment: |
Western blot |
| Target gene description: |
We found increased TXNIP expression in VEC incubated with 10 lM 4-HNE for 7 days.TXNIP expression was increased in VEC co-cultured with foam-cells. The 4-HNE scavenger FL926-A16 decreased TXNIP expression in VEC co-cultured with foam cells.The selective PPARd antagonist GSK0660 abolished 4-HNE effects on the expression of the different senescence markers and prevented the upregulation of TXNIP. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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