External factors
| External factors: |
Estrogen |
| Category: |
Chemical compounds |
| Phenotype: |
Werner syndrome |
| Experiment: |
SA-β-gal activity assay//Western blot |
| Description: |
Estrogen was able to block the adriamycin-induced DcR2 and p16/INK4A, molecular markers of senescence. SA-β-Gal staining also showed a similar pattern so that estrogen was able to block the adriamycin-induced senescence . |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
The transcript of WRN was induced by estrogen treatment in a time-dependent manner. In the same cell line, we could also observe the induction of WRN protein expression. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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