External factors
| External factors: |
Estrogen |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
The addition of 1 nM beta-estradiol to MCF-7 cells grown in charcoal-stripped serum brought the level of cellular senescence down to 35% β-galactosidase positive cells. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
YPEL3 |
| Target gene experiment: |
SA-β-gal activity assay//RT-PCR//Knockdown |
| Target gene description: |
In contrast, shLacZ expressing MCF-7 cells did show the expected induction of cellular senescence when grown in charcoal-stripped serum. Knockdown of YPEL3 expression was confirmed with relative mRNA expression. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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