External factors
| External factors: |
PD-0332991 |
| Category: |
Chemical compounds |
| Phenotype: |
Esophageal cancer |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Treatment with PD-0332991 drastically increased the activity of SA-β-gal, a marker for senescent cells in EC109 and EC9706 cells. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
FOXM1 |
| Target gene experiment: |
Western blot//SA-β-gal activity assay |
| Target gene description: |
Western blotting analysis revealed that the protein level of FOXM1 was decreased by PD-0332991 in a concentration-dependent manner. Importantly, compared with si-control transfection, knockdown of FOXM1 obviously potentiated the PD-0332991-induced cellular senescence, as indicated by a significant increase in the percentage of SA-β-gal positive cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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