External factors
| External factors: |
Metformin |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Exposure of MEFs to metformin as a single agent augmented baseline senescence measured as the percentage of cells that have SA-β-gal activity between approximately 3 4-fold. |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
383
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
MIR-200A |
| Target gene experiment: |
qRT-PCR |
| Target gene description: |
When a 2-fold or greater difference in miRNA expression levels was used as the cut-off to determine significant regulatory effects on miRNAs involved in the EMT/ MET genetic program, we found that miR-200a (more than 20-fold), miR-141 and miR-429, three members of the miRNA200 family, were markedly upregulated in HDFs that have undergone SIS in response to metformin compared with young and old BJ-1 untreated fibroblasts . |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793