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Aging Overview

External factors

External factors: Aspirin
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: HUVEC
PMID: 19520256
Experiment: SA-β-gal activity assay
Description: Treatment with aspirin decreased SA-β gal–positive cells and expression of PAI-1, but treatment with ticlopidine or clopidogrel did not have any effect on them.



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Regulatory relationship

Target gene: PAI-1
R-EF-Target gene: Downregulation
Official symbol(s): SERPINE1
Target gene experiment: Western blot
Target gene description: Treatment with aspirin decreased SA-β gal–positive cells and expression of PAI-1, but treatment with ticlopidine or clopidogrel did not have any effect on them.


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Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.




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