External factors
| External factors: |
Carbamide peroxide |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Western blot |
| Description: |
In the myeloma cell KM-HM_(31), CP treated cell and increased levels of aging proteins P53 and P16, indicating the establishment of a successful aging model for further studies. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
SIRT6 |
| Target gene experiment: |
Western blot |
| Target gene description: |
We further observed that in cell aging model, Sirtuin 6 level was apparently increased, indicating the possible role of Sirtuin 6 to CP-induced myeloma cell KM-HM_(31) aging. |
| Regulatory pathway:
|
Hippo |
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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STK4
|
| Pathway experiment: |
Western blot |
| Pathway description: |
Also, the evident reduction of Hippo was found in myeloma cell aging model compared to normal control. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.