External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Immunostaining |
| Description: |
We observed that feeding with LG2055 delayed aging, with intestinal lipofuscin( a marker of cellular damage during aging) levels being 12% lower in LG2055-fed worms than in OP50-fed worms. However, the ratio of stained area in the whole body was decreased in LG2055-fed worms compared with that in OP50-fed worms. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
POU2F3 |
| Target gene experiment: |
GFP localization assay |
| Target gene description: |
We observed that extrachromosomal and integrated transgenes driving skn-1c–gfp expression from ges-1 promoter 16 induced stronger fluorescence in LG2055-fed worms than in OP50-fed worms. |
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| Regulatory pathway:
|
p38 MAPK |
| Pathway experiment: |
Western blot |
| Pathway description: |
We observed that feeding with LG2055 altered the expression of genes involved in p38 MAPK signaling ；In addition, levels of phosphorylated p38 were increased in LG2055-fed worms . |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Pathway view
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