External factors
| External factors: |
Sirolimus |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis |
| Description: |
Treatment with paclitaxel, sirolimus, and everolimus significantly induced a senescent phenotype as judged by SA-βgal and an enlarged, flattened cell morphological appearance at 10 days. |
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Regulatory relationship
| Target gene:
|
PAI-1//ENOS//SIRT1 |
| R-EF-Target gene:
|
Upregulation//Downregulation//Downregulation |
| Official symbol(s): |
SERPINE1//ENOS//SIRT1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
In parallel with SA-βgal, expression of PAI-1 was increased by treatment with paclitaxel, sirolimus, and everolimus .Paclitaxel, sirolimus, and everolimus decreased the expression of eNOS and Sirt1. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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