External factors
| External factors: |
G-quadruplex interActivate agent S2T1-6OTD |
| Category: |
Chemical compounds |
| Cell name: |
D341,D425,Daoy ,BT-12,BT-16 |
| Experiment: |
Telomere length assay//SA-β-gal activity assay//Cell morphological analysis |
| Description: |
Treatment with S2T1-6OTD at 0.04 μmol/L resulted in telomere shortening in all MB and AT/RT cells tested.The morphologic examination of the 0.04 μmol/L S2T1- 6OTD–treated cells at the plateau phase showed an increased proportion of flat and giant cells with phenotypic characteristics of senescence and positive for senescence-associated β-galactosidase. |
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Regulatory relationship
| Target gene:
|
C-MYC//HTERT |
| R-EF-Target gene:
|
Downregulation//Downregulation |
| Official symbol(s): |
C-MYC//HTERT |
| Target gene experiment: |
qRT-RCR//ELISA |
| Target gene description: |
Treatment with S2T1-6OTD resulted in significant reductions of c-Myc mRNA and protein expression in all other MB and AT/RT cell lines tested .it was found that S2T1-6OTD could indeed reduce hTERT mRNA expression in BT-12, BT-16, DAOY ,and D341 cells.S2T1-6OTD reduced telomerase activity in all cell lines tested, with maximum inhibition in D341 (64%) and a minimum 17% in D425. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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