External factors
| External factors: |
Resveratrol |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Resveratrol influenced EPCs senescence dose dependently, with a maximal inhibitory effect achieved at 50mM. |
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Regulatory relationship
| R-EF-Target gene:
|
Activation |
| Official symbol(s): |
TELOMERASE |
| Target gene experiment: |
Western blot |
| Target gene description: |
Resveratrol dose dependently increased telomerase activity, with a maximal increase at 50mM. |
| Regulatory pathway:
|
PI3K-Akt |
| Official symbol(s): |
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PIK3CB-AKT
|
| Pathway experiment: |
Western blot |
| Pathway description: |
Stimulation with resveratrol led to dose-dependent phosphorylation of Akt, although it did not affect the total amount of Akt. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.