External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Ang II induced a dose-dependent increase in the fraction of cells staining positive for β-galactosidase, indicating an increased fraction of senescent cells. |
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Regulatory relationship
| Target gene:
|
TERT//UCP2//P-AKT//C-MYC//P53 |
| R-EF-Target gene:
|
Upregulation//Upregulation//Upregulation//Upregulation//Upregulation |
| Official symbol(s): |
TERT//UCP2//P-AKT//C-MYC//P53 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Incubation with Ang II further elevated TERT protein levels from 0.006±0.041 at baseline, to 0.480±00.031 in the presence of 10 lM Ang II, UCP2 protein levels from 0.297±0.051 to 2.512±0.024, p-Akt protein levels from 0.012± 0.024 to 0.874± 0.015, c-myc protein levels from 0.521 ±0.015 to 1.064± 0.025, and p53 protein levels from 0.035± 0.047 to 1.195 ±0.029 but Akt levels were not significantly affected by incubation with even 10 lM Ang II. |
| Regulatory pathway:
|
PI3K-Akt |
| Official symbol(s): |
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PIK3CB-AKT
|
| Pathway experiment: |
SA-β-gal activity assay |
| Pathway description: |
β-Galactosidase staining indicated a decline in the fraction of senescent cells with increasing LY concentration. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.