External factors
| External factors: |
Tamoxifen |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Similarly, there was a 35% induction of cellular senescence in tamoxifen-treated shLacZ cells that was not observed in either pool of MCF-7 cells expressing shYPEL3. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
YPEL3 |
| Target gene experiment: |
RT-PCR |
| Target gene description: |
There was a 2.3-fold induction of YPEL3 mRNA expression in control cells (shLacZ) treated with tamoxifen verses vehicle control. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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