External factors
| External factors: |
Telomestatin |
| Category: |
Chemical compounds |
| Experiment: |
Immunostaining |
| Description: |
Treatment of HT1080 cells with 1, 2, and 5μM telomestatin for 48 h induces a dose-dependent decrease of the G-overhang signal, which represents 32, 15, and 10% of the untreated control, respectively.Telomestatin treatment induces a marked DNA damage response evidenced by a strong increase in theγH2AX foci.Interestingly, the exposure of HT1080 cells to telomestatin (2μM)induces a rapid telomere shortening detectable after short term treatment. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation//Downregulation |
| Official symbol(s): |
POT1//TERF2 |
| Target gene experiment: |
Immunostaining |
| Target gene description: |
Telomestatin treatment of HT1080 cells(2μM,48 h) induced a noticeable decrease of the TRF2 signal at telomeres .Telomestatin strongly reduced the GFP-POT1 punctated signal associated with telomeres to nearly undetectable levels, as compared with untreated controls.The dose-dependent effect of telomestatin was also studied in HT1080GFP-POT1 cells after 48 h of treatment. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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