External factors
| Category: |
Chemical compounds |
| Cell name: |
Human interfollicular epidermal stem cell |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Morin significantly inhibited UVB-induced accumulation of SA-β -gal in KSC. |
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Regulatory relationship
| Target gene:
|
TNF-α//IL-1 β//IL-6 |
| R-EF-Target gene:
|
Downregulation//Downregulation//Downregulation |
| Official symbol(s): |
TNF//IL1B//IL6 |
| Target gene experiment: |
ELISA |
| Target gene description: |
However, morin led to a significant decrease in the production of TNF- α , IL-1 β , and IL-6 in the UVB-irradiated KSC. |
| Official symbol(s): |
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ATM
|
| Pathway experiment: |
Flow cytometry//Western blot |
| Pathway description: |
Flow cytometric result showed that fl uorescence intensity of ATM phosphorylation was 74.7% value in the morin-treated KSC compared with 86.1% value in UVB-irradiated KSC. As a result, ATM-related signaling pathway molecules (Chk2, p53, and H2A.X), MAPK family members (JNK/SAPK and p38/MAPK), and S6RP were rapidly phosphorylated in response to UVB irradiation in KSC . |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.