| Gene name: | BRD4 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | KYSE450 |
| Gene ID: | 23476 |
| Category: | protein coding |
| Phenotype: | Oesophageal cancer |
| Experimental category: | L |
| PMID: | 32954665 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | Treated with 125nM JQ1 for 6 days, the SA-β-gal?positive cells significantly rose and increased subsequently in a ?dose-dependent manner.Immunoblotting also demonstrated that ?JQ1 increased p21 protein level within 6 days in KYSE450 cells. |
| Target gene: | AURKA//AURKB |
| Official symbol(s): | AURKA//AURKB |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//ChIP-Qpcr |
| Target gene description: | Western blot analysis also showed that AURKA and AURKB protein were time- and ?dose-dependently decreased following JQ1 treatment. Data of ChIP-qPCR ?revealed that JQ1 suppressed BRD4 binding on the promoters of ?AURKA and AURKB genes in KYSE450 cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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