| Gene name: | RECQL4 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | ESCC tissues |
| Cell name: | KYSE30,KYSE450,KYSE410,KYSE150,TE-1 |
| Gene ID: | 9401 |
| Category: | protein coding |
| Phenotype: | Esophageal cancer |
| Experimental category: | HL |
| PMID: | 33628589 |
| Experiment: | Western blot//SA-β-gal activity assay |
| Description: | Approximately 45% of KYSE30 RECQL4-depleted cells and 30% of TE-1 RECQL4-depleted cells showed positive SA-β-gal staining. The expression of p21, an effector molecule of G1 arrest and cellular senescence, was also increased significantly, which is consistent with previous studies. |
| Target gene: | C-MYC//CYCLIND//CDK6//CYCLINE |
| Official symbol(s): | C-MYC//CYCLIND//CDK6//CYCLINE |
| R-AG-Target gene: | Downregulation//Downregulation//Upregulation//Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | To further investigate how RECQL4 regulates G1/S phase ?transition and cellular senescence, we determined the expres?sion of other related proteins. Depletion of RECQL4 led to decreased expression of c-myc, cyclin D, ?CDK6, and cyclin E. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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