| Gene name: | SLX4IP |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | DU145,PC-3 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | As expected, a considerable increase in the proportion of senescence-associated β-galactosidase (SA β-gal) staining was observed in late-passage cells with SLX4IP knockdown compared with late-passage controls. Elevations in relative p21 protein expression, a senescence-associated marker, further corroborated the senescent phenotype. Moreover, SLX4IP knockdown led to a prominent increase in both β-gal positively stained cells and relative p21 protein expression in late-passage DU145-derived cell lines that were not present in early-passage cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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