| Gene name: | FBP1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HSC |
| Experiment: | SA-β-gal activity assay//IHC staining |
| Description: | We detected significant numbers of SA-β-Gal+ cells in DEN/Cre livers through senescence-associatedβ-galactosidase (SA-β-Gal) staining. Representative SA-β-Gal and CD140B IHC staining of cryosections from mouse liver sections at 36 weeks. Representative p21 and FOXO4 IHC staining of mouse liver sections at 36 weeks. |
| Target gene: | HMGB1 |
| Official symbol(s): | HMGB1 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | IF//Immunoblotting |
| Target gene description: | We therefore treated DEN/GFP or DEN/Cre animals with inflachromene (ICM), a small molecule shown to block HMGB1 release45. ICM treatment greatly reduced not only surface tumours, but also microscopic lesions in DEN/Cre mice. ICM did not affect hepatic steatosis, based on comparable TG levels. As expected, cytosolic HMGB1 levels decreased while nuclear HMGB1 levels increased in ICM-treated livers. ICM also substantially reduced numbers of HSCs expressing SASP components. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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