| Gene name: | MTOR |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Fibroblasts |
| Experiment: | Western blot//SA-β-gal activity assay |
| Description: | Serum-starved fibroblasts exposed to R showed lowered CDNK1A and CDKN2A protein levels and decreased SA-GLB1/β-gal activity.RICTOR silencing suppressed AKT1 phosphorylation at Ser473 along with repression of myofibroblast differentiation inhibition of CDKN1A and CDKN2A expression, and inhibition of SA-GLB1/β-gal activity RPTOR silencing led, however, to inhibition of SA-GLB1/β-gal activity .We silenced RICTOR and RPTOR concomitantly in serum-starved fibroblasts. |
| Target gene: | AKT1 |
| Official symbol(s): | AKT1 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Phosphorylation |
| Target gene experiment: | Western blot//SA-β-gal activity assay |
| Target gene description: | RICTOR silencing suppressed AKT1 phosphorylation at Ser473 along with repression of myofibroblast differentiation inhibition of CDKN1A and CDKN2A expression, and inhibition of SA-GLB1/β-gal activity. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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