| Gene name: | MIR29A |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Embryo |
| Cell name: | MEF |
| Experiment: | SA-β-gal activity assay |
| Description: | Increased abundance of miR-29 (represented miR-29a and miR-29c hereinafter) in early passaged cells (PD4) accelerated senescence whereas decreased amounts of miR-29 in late passaged cells (PD8) delayed senescent phenotypes. |
| Target gene: | H4K20ME3 |
| Official symbol(s): | H4K20ME3 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Furthermore, forced expression or inhibition of miR-29, by individual transfection of miRNA mimics (M-miR-29) or inhibitors (I-miR-29a and I-miR-29c), resulted in decreased or increased H4K20me3 abundance, respectively. Gain of function of miR-29 via lentiviral infection led to reduced protein levels of Suv4-20h and H4K20me3. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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