| Gene name: | MIR30C1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Pancreas |
| Cell name: | BJ |
| Experiment: | Cell proliferation assay//SA-β-gal activity assay//qRT-PCR//Growth curve assay |
| Description: | Increased expression of each of the 5 miR-30 family members abrogated induction of proliferative arrest and SA-β-gal by HarasV12 in BJ cells .We detected less SA-β-gal positive epithelial cells in PanIN lesions from the miR-30c-1 transgenic than the control pancreas. |
| Target gene: | CHD7//TNRC6A//P16//P53 |
| Official symbol(s): | CHD7//TNRC6A//P16//P53 |
| R-AG-Target gene: | Downregulation//Downregulation//Downregulation//Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR |
| Target gene description: | All 5 miR-30 members inhibited the expression of endogenous CHD7 and TNRC6A mRNA in BJ cells;Corresponding to reduced senescence in the skin tumors from miR-30c transgenic mice, these tumors contained less cells positive for γH2AX or activated p53 (p53-pS15), indicating abrogation of DDR, and less p16INK4A-positive cells, as compared to those from wild-type littermates . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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