AgingReG
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Aging Overview

Aging gene

Gene name: MIR370
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: A549
Gene ID: 442915
Category: ncRNA
Phenotype: Lung cancer
Experimental category: L
PMID: 28631573
Experiment: SA-β-gal activity assay//Colony formation assay
Description: Positive β-galactosidase cells were observed to increase prominently following transfection of the miR-370.miR-370 was obviously suppressed the number of colonies.

Regulatory relationship

Target gene: P21
Official symbol(s): P21
R-AG-Target gene: Upregulation
Subcategory: Unclear
Target gene experiment: Flow cytometry//SA-β-gal activity assay//Colony formation assay
Target gene description: Flow cytometry analysis suggested that cotransfection of miR-370 with siP21 remarkably attenuated Go/G1 cycle arrest.Silencing p21 dramatically inhibited miR-370 induced cell senescence.The ability of proliferation and colony formation were restored by p21 silencing.

Regulatory pathway: CCND1-CDK4//CCND1-CDK6
R-AG-Pathway: Downregulation
Official symbol(s): CCND1-CDK4//CCND1-CDK6
Pathway experiment: qRT-PCR
Pathway description: As is shown, compared to dsControl treatment, positive control (dsP21-322), miR-370 significantly downregulated expression of Cyclin D1 and CDK4/CDK6 mRNA in A549 .

Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.


Pathway view

AndrogenReceptorAP-1 transcription factor networkATF-2 transcription factor networkC-MYB transcription factor networkCoregulation of Androgen receptor activityCyclin D associated events in G1E-cadherin signaling in the nascent adherens junctionFOXA1 transcription factor networkFOXM1 transcription factor networkIntegrin-linked kinase signalingNeurotrophic factor-mediated Trk receptor signalingNotch signaling pathwayPre-NOTCH Transcription and TranslationPresenilin action in Notch and Wnt signalingProlactinPTK6 Regulates Cell CycleRegulation of nuclear beta catenin signaling and target gene transcriptionRegulation of retinoblastoma proteinRegulation of TelomeraseRMTs methylate histone argininesSCF(Skp2)-mediated degradation of p27/p21Signaling events mediated by focal adhesion kinaseSignaling mediated by p38-gamma and p38-deltaTGF_beta_ReceptorTrk receptor signaling mediated by PI3K and PLC-gammaUbiquitin-dependent degradation of Cyclin D1Validated nuclear estrogen receptor alpha networkValidated targets of C-MYC transcriptional repressionValidated transcriptional targets of AP1 family members Fra1 and Fra2WntCell cyclep53 signaling pathwayWnt signaling pathwayFocal adhesionJak-STAT signaling pathwayPathways in cancerColorectal cancerPancreatic cancerEndometrial cancerGliomaProstate cancerThyroid cancerMelanomaBladder cancerChronic myeloid leukemiaAcute myeloid leukemiaSmall cell lung cancerNon-small cell lung cancerViral myocarditisHs_Cytokines_and_Inflammatory_Response_WP530_79331Hs_miRNAs_involved_in_DNA_damage_response_WP1545_84697Hs_MAPK_Signaling_Pathway_WP382_79951Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941Hs_Copper_homeostasis_WP3286_89205Hs_Bladder_Cancer_WP2828_89143Hs_IL-7_Signaling_Pathway_WP205_89854
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) ATF-2 transcription factor networkBCRCalcineurin-regulated NFAT-dependent transcription in lymphocytesCyclin D associated events in G1Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) FOXM1 transcription factor networkMeiotic recombinationOncogene Induced SenescenceOxidative Stress Induced SenescencePositive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) PTK6 Regulates Cell CycleRegulation of nuclear SMAD2/3 signalingRegulation of retinoblastoma proteinRMTs methylate histone argininesSCF(Skp2)-mediated degradation of p27/p21Senescence-Associated Secretory Phenotype (SASP)TGF_beta_ReceptorTranscriptional regulation of white adipocyte differentiationTSHUbiquitin-dependent degradation of Cyclin D1Validated targets of C-MYC transcriptional activationVEGF signaling pathway ( VEGF signaling pathway ) Cell cyclep53 signaling pathwayTight junctionT cell receptor signaling pathwayPathways in cancerPancreatic cancerGliomaMelanomaBladder cancerChronic myeloid leukemiaSmall cell lung cancerNon-small cell lung cancerHs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941Hs_Integrated_Cancer_Pathway_WP1971_82939
AndrogenReceptorAP-1 transcription factor networkATF-2 transcription factor networkC-MYB transcription factor networkCoregulation of Androgen receptor activityCyclin D associated events in G1E-cadherin signaling in the nascent adherens junctionFOXA1 transcription factor networkFOXM1 transcription factor networkIntegrin-linked kinase signalingNeurotrophic factor-mediated Trk receptor signalingNotch signaling pathwayPre-NOTCH Transcription and TranslationPresenilin action in Notch and Wnt signalingProlactinPTK6 Regulates Cell CycleRegulation of nuclear beta catenin signaling and target gene transcriptionRegulation of retinoblastoma proteinRegulation of TelomeraseRMTs methylate histone argininesSCF(Skp2)-mediated degradation of p27/p21Signaling events mediated by focal adhesion kinaseSignaling mediated by p38-gamma and p38-deltaTGF_beta_ReceptorTrk receptor signaling mediated by PI3K and PLC-gammaUbiquitin-dependent degradation of Cyclin D1Validated nuclear estrogen receptor alpha networkValidated targets of C-MYC transcriptional repressionValidated transcriptional targets of AP1 family members Fra1 and Fra2WntCell cyclep53 signaling pathwayWnt signaling pathwayFocal adhesionJak-STAT signaling pathwayPathways in cancerColorectal cancerPancreatic cancerEndometrial cancerGliomaProstate cancerThyroid cancerMelanomaBladder cancerChronic myeloid leukemiaAcute myeloid leukemiaSmall cell lung cancerNon-small cell lung cancerViral myocarditisHs_Cytokines_and_Inflammatory_Response_WP530_79331Hs_miRNAs_involved_in_DNA_damage_response_WP1545_84697Hs_MAPK_Signaling_Pathway_WP382_79951Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941Hs_Copper_homeostasis_WP3286_89205Hs_Bladder_Cancer_WP2828_89143Hs_IL-7_Signaling_Pathway_WP205_89854
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) BCRC-MYB transcription factor networkCoregulation of Androgen receptor activityCyclin D associated events in G1Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) IL2 signaling events mediated by STAT5Oncogene Induced SenescenceOxidative Stress Induced Senescencep73 transcription factor networkPositive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) Regulation of retinoblastoma proteinSenescence-Associated Secretory Phenotype (SASP)TGF_beta_ReceptorVEGF signaling pathway ( VEGF signaling pathway ) WntCell cyclep53 signaling pathwayPathways in cancerPancreatic cancerGliomaMelanomaChronic myeloid leukemiaSmall cell lung cancerNon-small cell lung cancerHs_miRNAs_involved_in_DNA_damage_response_WP1545_84697
About risk SNP and eQTL

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Data source of:
Expression of gene(s)
Cell line (ENCODE) Primary cell (ENCODE) Normal tissue (GTEx) Cell line (CCLE)