| Gene name: | MIR138-1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | SN-12 |
| Experiment: | SA-β-gal activity assay |
| Description: | Ninety-six hours after introducing the miR-138 mimic, the results revealed that overexpression of miR-138 significantly increased the number of SA-β-gal-positive cells compared with those of the scrambled miRNA mimic. |
| Target gene: | E2H2 |
| Official symbol(s): | E2H2 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Luciferase reporter assay//SA-β-gal activity assay//Knockdown |
| Target gene description: | The transfection of this reporter construct in the presence of miR-138 mimic induced nearly a 50% downregulation of relative luciferase activity; this effect was abolished with the mutation of miR-138 at the putative target site.Knockdown of EZH2 induced senescence in SN-12 cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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