| Gene name: | RB1 |
| Aging type: | Accelerate |
| Aging characteristic: | Others |
| Tissue type: | Bone |
| Cell name: | Primary human bone cell |
| Gene ID: | 5925 |
| Category: | protein coding |
| Phenotype: | Retinoblastoma |
| Experimental category: | HL |
| PMID: | 24231354 |
| Experiment: | Knockdown//SA-β-gal activity assay//qRT-PCR |
| Description: | Consistent with a role in senescence, radiation-induced expression of Il1b, Il6, Il8/Mip2, and Mcp1 was markedly attenuated in Rb1fl/fl mice relative to that in wild-type mice . Confirming these findings, ex vivo studies using 4 Gy IR also showed decreased SA-β-Gal–positive staining (data not shown) and reduced protein expression of IL-6 and MCP-1 in calvaria from Rb1fl/fl mice compared with that in wild-type mice. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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