| Gene name: | PRKCA |
| Aging type: | Accelerate |
| Aging characteristic: | Others |
| Tissue type: | -- |
| Cell name: | TIG-1,Human normal diploid cell |
| Experiment: | SA-β-gal activity assay//Growth curve assay |
| Description: | Adenoviral transduction of PKC-δ induced growth inhibition in TIG-1 cells. Bistratene A, a PKC-d activator, also strongly inhibited the growth of TIG-1 cells . Furthermore, PKC-δ transduction and activation caused enlarged and flattened cell morphology and augmented SA-β-Gal activity in TIG-1 cells, as was observed in the senescent TIG-1 cells. |
| Target gene: | HTERT |
| Official symbol(s): | HTERT |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR |
| Target gene description: | We investigated whether PKC-δ when activated in senescent cells functions in repression of the hTERT gene. The results showed that hTERT repression in senescent TIG-1 cells was relieved following infection with PKC-δ-KN, demonstrating that PKC-δ functions in the repression of the hTERT gene in senescent cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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