| Gene name: | EPHA3 |
| Aging type: | Prevent |
| Aging characteristic: | Others |
| Tissue type: | -- |
| Cell name: | hTERT-RPE1 |
| Experiment: | SA-β-gal activity assay |
| Description: | Our results showed that senescence was uniquely detected after knockdown of EPHA3 and not measurably apparent after knockdown of other EPHA RTKs expressed in hTERT-RPE1 cells . |
| Regulatory pathway: | P16//P53 |
| R-AG-Pathway: | --//-- |
| Official symbol(s): | CDKN2A//TP53 |
| Pathway experiment: | qRT-PCR//Immunostainings//Knockdown |
| Pathway description: | Characterization of the senescence signature showed that siRNA-mediated knockdown of EPHA3 leads to increased p16INK4a and p53 expression . |
Annotation:
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