| Gene name: | ITGB4 |
| Aging type: | Accelerate |
| Aging characteristic: | Others |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Experiment: | SA-β-gal activity assay |
| Description: | The percentage of positive cells increased significantly during VEC aging.The percentage of SA-βgal positive cells in integrin β4 siRNA treatment group (43.84% 2.17%) was much lower than that in the control group (59.65% 2.74%). |
| Target gene: | PC-PLC//P53 |
| Official symbol(s): | PLCB1//P53 |
| R-AG-Target gene: | Downregulation//Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | PC-PLC activity assay//Western blot |
| Target gene description: | As a result, Ca2+-dependent PC-PLC was nearly not changed, but the activity of Ca2+-independent PC-PLC decreased obviously during senescence.Down-regulation of integrin β4 depressed P53 and ROS levels and inhibited the activity of Ca2+-independent PC-PLC significantly. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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