| Gene name: | WNT2 |
| Aging type: | Prevent |
| Aging characteristic: | Others |
| Tissue type: | -- |
| Cell name: | RPE,WI-38 |
| Experiment: | DAPI staining//SAHF//SA-β-gal activity assay//Knockdown |
| Description: | There was a good correlation between knockdown of Wnt2 and recruitment of HIRA to PML bodies, formation of SAHF judged by DAPI staining, and expression of SA β-gal.Strikingly, Wnt3aconditioned medium or purified recombinant Wnt3a delayed HIRA s localization to PML bodies and formation of SAHF in cells passaged toward senescence .Likewise, exogenous Wnt3a delayed onset of cell senescence caused by extended growth of WI38 cells in culture. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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