| Gene name: | PCGF2 |
| Aging type: | Accelerate |
| Aging characteristic: | Others |
| Tissue type: | -- |
| Cell name: | MRC-5 |
| Experiment: | SA-β-gal activity assay |
| Description: | Mel-18 overexpression led to inhibition of cellular proliferation and induction of premature senescence in MRC-5 fibroblasts as determined by SA-β-gal staining. |
| Target gene: | BMI-1//C-MYC |
| Official symbol(s): | BMI-1//C-MYC |
| R-AG-Target gene: | Downregulation//Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Knockdown |
| Target gene description: | Our results indicated that similar to MRC-5 fibroblasts, stable overexpression of Mel-18 results in Bmi-1 down-regulation in MCF10A and MCF7 cells.Mel-18 overexpression led to down-regulation of c-Myc in multiple cell types.Western blot analysis of cells expressing Mel-18 shRNAs showed significant down-regulation of Mel-18 and up-regulation of Bmi-1 in these multiple cell types.As expected, knockdown of Mel-18 also up-regulated c-Myc expression. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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