| Gene name: | IRF3 |
| Aging type: | Accelerate |
| Aging characteristic: | Others |
| Tissue type: | -- |
| Cell name: | BJ,IMR-90 |
| Experiment: | Cell counting//SA-β-gal activity assay//Knockdown |
| Description: | overexpression of IRF3 in BJ and IMR90 cells was shown to decrease the rate of cell proliferation and increase the senescence cell population,as determined by senescence-associated β-galactosidase staining assay.When the cellular life span was determined by 3T6 cell culture protocol, IRF3-knockdown BJ cells were found to increase the cell proliferation rate and life span. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | Activation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | We found that p53 mRNA was not increased by IRF3, but p53 protein and its downstream target p21WAF1 were upregulated in IRF3-overexpressing BJ cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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