| Gene name: | TET1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Lung |
| Cell name: | H1299,H1975,H226 |
| Gene ID: | 80312 |
| Category: | protein coding |
| Phenotype: | Lung cancer |
| Experimental category: | HL |
| PMID: | 30622117 |
| Experiment: | SA-β-gal activity assay |
| Description: | Cell morphology (enlarged size and flattened shape) suggested that these cells were undergoing cellular senescence and this was confirmed by analyzing the cells for β-galactosidase activity, a metabolic marker of senescence. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | Inhibition |
| Subcategory: | Binding to promoter |
| Target gene experiment: | IP |
| Target gene description: | Thus, the hypothesis that WT p53 negatively regulates TET1 transcription via direct binding to its promoter was tested with ChIP using a p53-specific antibody. As expected, no enrichment of p53 at its predicted binding site within the TET1 promoter region was detected in H1299 cells characterized by a p53-null mutation. Conversely, 23,800- and 13,500-fold enrichments of p53 at the TET1 promoter were found in the WT p53 cell lines A549 and H2228, respectively. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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