| Gene name: | DUSP3 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HeLa,MEWO |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | The results indicated that decreasing endogenous DUSP3 activity per se caused increased cellular senescence of both cell lines after 72 h (20-30%). As expected, cells exposed to 5 Gy of gamma radiation exhibited increased SA-β-Gal staining, which was further significantly increased in the cells subjected to the combined gamma radiation/DUSP3 inhibitor treatment and reached 40-60% in the HeLa and MeWo cells, indicating that these cells tended to undergo senescence in response to pharmacological DUSP3 inhibition. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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