| Gene name: | SIRT6 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Fibroblast,HCA2-HR |
| Experiment: | Immunocytochemistry |
| Description: | SIRT6 overexpression reduces the number of γH2AX foci in presenescent cells. |
| Target gene: | PARP1//RAD51//RAD51C//RAD52//NBS1//SIRT6//CTIP |
| Official symbol(s): | PARP1//RAD51//RAD51C//RAD52//NBN//SIRT6//CTIP |
| R-AG-Target gene: | Activation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | In the presence of PJ34, SIRT6 overexpression had no effect on HR,indicating that SIRT6-mediated rescue of HR in aging cells is dependent on PARP1.Western blot showing overexpression of HR-related proteins in HCA2-HR cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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