| Gene name: | MYC |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | AG00780,AG03141,Fibroblast |
| Gene ID: | 4609 |
| Category: | protein coding |
| Phenotype: | Werner syndrome |
| Experimental category: | HL |
| PMID: | 12842909 |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | However, within 2–3 passages, ～30%–70% of the WRN–/– cells expressed senescence-associated (SA-) β-galactosidase and lost proliferative capacity. The senescent phenotype in c-myc-transduced WRN–/– cells was also confirmed at the gene expression level by microarray analysis, which demonstrated elevated expression of several genes characteristic of replicative senescence, such as the matrix proteases. WRN–/– cells that were senescent by virtue of MYC overexpression were largely G1-arrested with a small G2 fraction (data not shown). |
| Target gene: | WRN |
| Official symbol(s): | WRN |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Flow cytometry |
| Target gene description: | We propose that WRN up-regulation by MYC may promote MYC-driven tumorigenesis by preventing cellular senescence. WRN–/– cells that were senescent by virtue of MYC overexpression were largely G1-arrested with a small G2 fraction (data not shown). |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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