| Gene name: | TERT |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HCT116 |
| Gene ID: | 7015 |
| Category: | protein coding |
| Phenotype: | Colorectal cancer |
| Experimental category: | HL |
| PMID: | 23284306 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | In both p53+ and p53? HCT116 cells, RNAi-mediated knockdown of TERT substantially increased the number of cells that stained positively for senescence-associated β-galactosidase activity, indicative of senescence induction. |
| Regulatory pathway: | P53 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TP53 |
| Pathway experiment: | SA-β-gal activity assay//Knockdown//Flow cytometry |
| Pathway description: | The level of senescence was higher in p53+ HCT116 TERT knockdown cells than in p53? HCT116 TERT knockdown cells, as expected, because p53-directed pathways contribute to senescence [1].In addition, knockdown of TERT increased the percentage of p53? HCT116 cells but not p53+ HCT116 cells in G2/M. |
Annotation:
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