| Gene name: | TERT |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Skin |
| Cell name: | DC,Fibroblast |
| Gene ID: | 7015 |
| Category: | protein coding |
| Phenotype: | Dyskeratosis congenita |
| Experimental category: | L |
| PMID: | 21087144 |
| Experiment: | Flow cytometry |
| Description: | TERT expressing DC-1 and normal cells had much higher telomerase activity.TERT-expressing DC cells exhibited a significant 50% decrease in both DHE and MitoSOX oxidation, relative to empty vector treated cells, demonstrating that overexpression of TERT in DC cells decreased steady-state levels of superoxide. |
| Regulatory pathway: | P53-P21 |
| R-AG-Pathway: | Downregulation |
| Official symbol(s): | TP53-CDKN1A |
| Pathway experiment: | Western blot |
| Pathway description: | TERT expression also reduced levels of phospho-p53 in DC cells. |
Annotation:
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