| Gene name: | HLX |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Experiment: | qRT-PCR//Knockdown//Flow cyotmetry |
| Description: | Depletion of INK4a expression rescued the cell cycle arrest triggered by HLX1 knockdown almost completely, indicating that INK4a is a key mediator of the effects of HLX1 on senescence. However, the knockdown of HLX1 still caused a small decline in BrdU incorporation in cells lacking p16INK4a expression, suggesting that HLX1 could also control senescence by additional mechanisms. |
| Target gene: | INK4A |
| Official symbol(s): | INK4A |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//qRT-PCR |
| Target gene description: | Depletion of INK4a expression rescued the cell cycle arrest triggered by HLX1 knockdown almost completely, indicating that INK4a is a key mediator of the effects of HLX1 on senescence. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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