| Gene name: | CDK4 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Mammary Gland |
| Cell name: | HMEC,keratinocyte |
| Experiment: | Growth curve assay |
| Description: | Overexpression of Cdk4mock infection in epidermal keratinocytes and HMECs extended their lifespan to 82 and 70 PD, respectively,compared to controls (in the absence of feeder layers 13 and 16 PD. |
| Target gene: | P16//P53//P21 |
| Official symbol(s): | P16//P53//P21 |
| R-AG-Target gene: | Upregulation//Upregulation//Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | The expression of p16INK4a was greatly elevated in Cdk4-overexpressing cells cultured in the absence of feeder layers.However, higher levels of p53 and upregulation of p21WAF1 was seen in cells overexpressing Cdk4 compared to uninfected controls. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...