| Gene name: | POT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Foreskin |
| Cell name: | HFF,BJ |
| Experiment: | SA-β-gal activity assay//Immunostaining//FISH |
| Description: | Suppression of hPOT1 in the HFF and BJ cells that had proliferated for the longest time in culture resulted in a 2- to 4-fold greater increase in doubling time as well as a marked induction in senescence-associated h-galactosidase (SA β-gal)staining. We found colocalization of γ-H2AX and telomeric foci in both early- and late-passage cells in which hPOT1 was suppressed. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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