| Gene name: | TBPL1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HCT116 |
| Gene ID: | 9519 |
| Category: | protein coding |
| Phenotype: | Colorectal cancer |
| Experimental category: | L |
| PMID: | 28082682 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | TLP-depleted cells exhibited resistance to senescence after UV irradiation. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//qRT-PCR |
| Target gene description: | The protein levels of both total p53 and Lys-382-acetylated p53, which is an activation marker for p53 transcriptional activity, were elevated within 4 h and decreased around 32–36 h after UV irradiation. Notably, TLP was significantly elevated around 32–36 h, and depletion of TLP accelerated the decrease of both total p53 and Lys-382-acetylated p53 during these time points . TLP-depleted cells clearly showed the reduction of p53 transcriptional activity in the late phase (at 32–48 h) of the UV response. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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