| Gene name: | ERBB4 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Saos-2,MG63.2 |
| Gene ID: | 2066 |
| Category: | protein coding |
| Phenotype: | Osteosarcoma |
| Experimental category: | HL |
| PMID: | 29524631 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | After 3, 5 and 7?days in monolayer culture, knockdown of endogenous HER4 significantly inhibited the proliferation of OS cells. Staining of tumor sections with SA-β-gal showed much higher senescence levels in shHER4 derived xenografts. Cytochemical analysis on SA-β-gal activity revealed that there was a dramatic increase of SA-β-gal-positive cells in shHER4 colonies as compared with scramble shRNA colonies. |
| Target gene: | PERK//P21//P27 |
| Official symbol(s): | EIF2AK3//P21//P27 |
| R-AG-Target gene: | --//--//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Knockdown |
| Target gene description: | We detected that the results showed that the senescence-associated protein p-ERK, p21 and p27 levels were increased in cells with HER4 knockdown. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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