| Gene name: | TFEB |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Lung |
| Cell name: | BEAS-2B |
| Gene ID: | 7942 |
| Category: | protein coding |
| Phenotype: | Chronic obstructive pulmonary disease |
| Experimental category: | L |
| PMID: | 27835930 |
| Experiment: | MTS assay |
| Description: | Our data shows that CSE-induced significant increase in ROS-activity is controlled by TFEB-induction, using GEM/FIS.Moreover, TFEBinduction by GEM/FIS also rescues the CSE-mediated decrease in cell viability as shown by the MTS assay.We and others have recently observed that tobacco-smoke/eCV exposure leads to cellular senescence ,via ROS-activation that accelerates lung aging and COPD-emphysema pathogenesis. We demonstrate here that CSE-mediated increase in number of senescent cells is significantly diminished by treatment with TFEB-inducing drugs, GEM/FIS. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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