| Gene name: | BMI1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Kidney |
| Cell name: | -- |
| Gene ID: | 648 |
| Category: | protein coding |
| Phenotype: | Renal tubulointerstitial injury |
| Experimental category: | L |
| PMID: | 24915841 |
| Experiment: | SA-β-gal activity assay |
| Description: | E-cadherin-positive renal tubules and the percentage of Ki67 positive renal cells were clearly decreased, whereas the percentages of senescence-associated-β-gal (SA-β-gal) positive area and TUNEL-positive cells were increased significantly in Bmi-1-/- mice, compared with wild-type mice. |
| Target gene: | γ-H2AX//PCHK2//P16//P19//P53//P21 |
| Official symbol(s): | H2AX//PCHK2//P16//P19//P53//P21 |
| R-AG-Target gene: | --//--//--//--//--//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Protein expression levels of c-H2A.X, pCHK2, p16, p19, p53, and p21 in kidneys were increased significantly in Bmi-1-/- mice, compared with wild-type mice. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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