| Gene name: | ERBB2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | DLD1 |
| Experiment: | SA-β-gal activity assay//qRT-PCR |
| Description: | HER2 ablation exaggerated this damage-induced cellular senescence, which was alleviated by HER2 reconstitution, suggesting that HER2 is responsible for the regulation of damage-induced senescence. |
| Target gene: | TBK1 |
| Official symbol(s): | TBK1 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | HER2 expression markedly inhibited the damage-induced TBK1 activation, indicating a critical role for HER2 in the regulation of DNA sensing during the cellular-damage response . |
| Regulatory pathway: | CGAS-STING |
| R-AG-Pathway: | Downregulation |
| Official symbol(s): | CGAS-STING1 |
| Pathway experiment: | Western blot |
| Pathway description: | HER2 suppressed STING- or TBK1-initiated signalling in a dosedependent manner but failed to suppress the activated IRF3 (5SD). |
Annotation:
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