| Gene name: | GAS2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | SK-HEP-1 |
| Gene ID: | 2620 |
| Category: | protein coding |
| Phenotype: | Hepatocellular carcinoma |
| Experimental category: | HL |
| PMID: | 25925944 |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | First,flow cytometry analysis revealed a significant elevation of sub-G1cell population upon overexpression of GAS2 .V ector-transfected SK-Hep1 cells were devoid of β-galactosidase (similar to mock-transfected control),whereas GAS2-overexpressed SK-Hep1 cells displayed induction of β-galactosidase. |
| Target gene: | P53//P21 |
| Official symbol(s): | P53//P21 |
| R-AG-Target gene: | Upregulation//Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Quantitative analysis demonstrated that up-regulation of GAS2 increased the number of β-galactosidase-positive cells by almost four-fold,accompanied by elevation of the senescence regulators p53 and p21, as determined by western blot. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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