| Gene name: | SPHK2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Spleen,Skin,Testes tissue |
| Cell name: | -- |
| Gene ID: | 56848 |
| Category: | protein coding |
| Phenotype: | Lung cancer |
| Experimental category: | HL |
| PMID: | 29748384 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | SphK2-/-mice exhibited accelerated senescence and aging phenotype measured by increased β-gal expression in their paws (37) at generation 6, and decreased weight of testes atgeneration4 or 5 compared with WT and SphK1-/-mice (generation matched controls). Examination of spleen,skin, and testes tissues at generation 6 using H&E staining also confirmed increased senescence and aging phenotype in SphK2-/-compared with WT mice. |
| Regulatory pathway: | P16 |
| R-AG-Pathway: | -- |
| Official symbol(s): | CDKN2A |
| Pathway experiment: | Immunofluorescence//Western blot |
| Pathway description: | ShRNA-mediated knockdown of SPHK2 induced caspase-3, and ectopic expression of p16 attenuated this process compared with Scr-shRNA– expressing A549 cells. |
Annotation:
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